With family support in Kansas City, we lived in Michigan, Indiana, Ohio, St Louis, South Carolina, southern Kansas, Oregon and Iowa. Four kids born in four different states.
A downside for our move to Michigan will be extra distance from family. Right now my wife can (and does) jump in the car and be there in an hour or so when needed.
A longer trip will result, but we will still be there when needed. We made it work then, it will work again.